Darren Tay graduated from the National University of Singapore (NUS) in 1999. He completed his orthopaedic residency training in 2009 and went on to undertake a clinical fellowship in hip and knee arthroplasty at Southampton General Hospital, UK, from 2010 to 2011.

He has been practising at Singapore General Hospital (SGH) as a senior consultant orthopaedic surgeon since 2016. He is currently the Head of the Orthopaedic Department at SGH since November 2024, and Academic Vice Chair (Clinical Services), Musculoskeletal Sciences ACP, since January 2025. In addition, he serves as a Clinical Associate Professor with Duke-NUS Graduate Medical School, Adjunct Associate Professor with the NUS Yong Loo Lin and Lee Kong Chian School of Medicine, and Physician Faculty in the SingHealth Orthopaedic Residency Programme.

Additionally, he is the specialty editor for Orthopaedics for the Singapore Medical Journal and past Chairman, Chapter of Orthopaedic Surgeons, Singapore. His main interests in adult reconstruction surgery are robotic-assisted surgery, minimally invasive partial knee resurfacing, and complex primary and revision surgery of the hip and knee.